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The expression of antioxidant protective genes and phase II detoxification enzyme genes induced by it can effectively reduce the sensitivity of liver cells to ROS and electrophiles, slow down the development of liver diseases, and prevent the occurrence and progress of liver fibrosis

The clinical appearance is one of the brown to black spots or macules, with a histopathological increase in melanin in the basal cell layer of the oral epithelium and melanin incontinence in the upper portion of the lamina propria, but without an increase in the number of melanocytes [11, 39, 40]

ICH Q2(R2) states that analytical procedures should be evaluated for characteristics such as specificity, selectivity, range, accuracy, precision, and robustness where applicable [13]

IV administration bypasses digestion, but this does not establish better clinical outcomes for general wellness, detoxification or longevity